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Dedicated, prospective studies with adequate sample sizes, long-term follow-up, and comprehensive metabolic phenotyping are urgently required to validate these preliminary observations and establish evidence-based, genotype-specific treatment approaches

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A First Look at the Numbers A 2026 study published in The Lancet Obstetrics, Gynaecology, and Women's Health took a direct look at this question, evaluating 120 postmenopausal women treated with tirzepatide, one of the most effective GLP-1 and GIP dual receptor agonists currently available [16]

PMID 16165177

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